Optofluidic ring resonator technology platform for rapid and sensitive biological and chemical sensing

Tuesday, February 10, 2009 (All day)
Dr. Xudong Fan

The optical ring resonator is an emerging sensing technology that has recently been under intensive investigation. In a ring resonator, light propagates in the form of whispering gallery modes (WGMs), which results in a light-analyte interaction length much longer than the resonator physical size. Consequently, the ring resonator can achieve a much improved detection limit, lower sample volume, and larger integration density than the traditional waveguide or optical fiber based sensor.

The optofluidic ring resonator (OFRR) is a unique technology platform developed in my lab in the past four years, which integrates microfluidics and photonics. The platform has a wide spectrum of applications, ranging from low-cost, portable, sensitive biomedical devices to highly sophisticated photonic instruments used in optical signal processing, nonlinear optics, and fundamental physics. In this talk, I will focus on three major biomedical applications of the OFRR:

1. OFRR label-free biosensors, including their working principles, performance advantages, and sensing examples (e.g., detection of protein, DNA, viruses, and cells such as MCF7 breast cancer cells and CD4+). Actual clinical applications of the OFRR for development of a portable and rapid breast cancer serological biomarker analyzer will be presented. Its potential applications for high throughput proteomics will also be discussed;

2. OFRR based micro-gas chromatography for chemical vapor sensing and its potential biomedical applications as a portable and sensitive breath analyzer;

3. OFRR microfluidic lasers and their applications in development of novel molecular beacon with ultrahigh sensitivity and ultralow sample volume.