Optical detection and optical therapies of bone cancer

Monday, June 1, 2009 (All day)
Vince Rossi
Speaker's Institution: 
Pacific University

My work aims at characterizing how light propagates through bone in order to efficiently guide treatment of osteosarcoma with photodynamic therapy (PDT).  Optical properties of various bone tissues need to be characterized in order to have a working model of light propagation in bone.  Bone tissues of particular interest include cortical bone, red and yellow marrow, cancellous bone, and bone cancers themselves.  With adequate knowledge of optical properties of osseous tissues, we can then determine how best to deliver adequate light to achieve phototoxic effects within bone.  An optical fiber source-collector pair is used for diffuse reflectance spectroscopic measurements in order to determine the scattering and absorption properties of cortical bone.  Optical properties are currently predicted for marrow and osteosarcoma based on physiology and blood concentrations.  The resulting optical properties of the layered osseous tissues are then used in a cylindrically symmetric Monte Carlo model in order to predict and guide the delivery of light within bone in order to achieve the desired phototoxic effect in PDT.