SPECIAL TIME & LOCATION - Mapping out nanoscale variations in hydration dynamics with magnetic resonance as applied to signal transduction, mesoporous materials, and energy storage.

Date: 
Thursday, January 8, 2015 - 2:00pm to Friday, January 9, 2015 - 10:00am
Speaker: 
John Franck
Speaker's Institution: 
University of California, Berkeley

Research Interests

Mapping out nanoscale variations in hydration dynamics with magnetic resonance as applied to signal transduction, mesoporous materials, and energy storage.    

Seminars

Thursday, January 8, 2pm, 331 Klamath Hall: Research Seminar 

Friday, January 9, 9am, 217 LISB: Future Research Workshop

Title and Abstract

"Mapping out Nanoscale Variations in Solvation Dynamics "

The water near macromolecular surfaces displays a colorful variation in dynamics. This "hydration water" modulates interactions in solution and plays a role in determining the structure of biomacromolecules -- yet, until recently, the methods available to characterize hydration water have remained relatively limited. We have developed a method for characterizing the equilibrium translational motion of water with 5-15 Å specificity. This method is based on dynamic nuclear polarization (DNP), a particularly sensitive variant of nuclear magnetic resonance (NMR). By investigating the hydration dynamics on the surface of lipid vesicles, a transmembrane protein, DNA, and the inside of a naturally occurring water nano-cavity, we demonstrate how liquid-state DNP can glean several insights into the structure and the function of bio-macromolecular systems.

Select Publications

J.M. Franck, M. Sokolovski, N. Kessler, E. Matalon, M. Gordon-Grossman, S.I. Han, D. Goldfarb, A. Horovitz. “Probing Water Density and Dynamics in the Chaperonin GroEL Cavity.” J. Am. Chem. Soc., 136(26):9396–403, 2014.

J.M. Franck, J.A. Scott, S. Han. “Nonlinear scaling of surface water diffusion with bulk water viscosity of crowded solutions.” J. Am. Chem. Soc., 135(11):4175–8, 2013.

 

J.M. Franck, A. Pavlova, J.A. Scott, S. Han. “Quantitative cw Overhauser effect dynamic nuclear polarization for the analysis of local water dynamics.” Prog. Nucl. Magn. Reson. Spectrosc., 74:33–56, 2013.